Mary M. Isbell 87 of Scottsville passed away at her residence on Thursday March 5, 2026.  she was born in St. Louis, MO to the late Edward & Vernice Hoesli.   She is also preceded in death by her husband Harmon G. Isbell, daughter Ladonna Penrose, son-in-law Tom Penrose, and son Edward Isbell.  She is survived by her daughter Patricia Singleton (Chuck) of Granite City, IL, Grandchildren Britney Croney, Melissa Pierce (James), great grandchildren Nathan Beck, Austin Croney (Lizette), Jamey Pierce, Rylan Grapes, & Shaun Allstun.  Mary was a Nurse Practitioner and owned a Book Store called Mary's Books.   Cremation was chosen and entrusted to Kirby Funeral Services Russellville.  Burial will take place at 1pm on April 23, 2026 in the Jackson Barricks in Saint Louis. Online Register book can be found at www.kirbyfuneralservices.com